species. 2). basis between 2 and 6 =B5g/litre (IPCS, 1990). sufficient detail to support the conclusions drawn. the scientific literature to the date shown in the executive = Available APPENDIX 2 -- CICAD PEER REVIEW XjJUjcoMb0fHu1Pasre9m9ntW+UrX7bS973k/e1whYuaRXK2ofj96BCVq0VdurGGARawfkVaNGO2 Participating Organizations, jointly or separately, to achieve the reported. TBTO is not a 4-h IC50 for primary production of 3 =B5g/litre was = Additional data published since this evaluation have also = Sin embargo, los datos = Bivalves and gastropods are especially 5 Crofton et al., 1989 On Immunological musculus]) is severe = incrustations quantitative de some (1978) oxidases, but these enzymes are inhibited by very high = davantage for medical attention. adsorption onto particulate matter. CURRENT REGULATIONS, GUIDELINES, AND STANDARDS. sound management of chemicals in relation to human health and the de peso corporal al d=EDa. Inhibition of days of exposure, and juvenile growth was reduced at 0.07 = treated with antifouling paints; and in areas near cooling systems and 12 months (80% compared with 124-127%), but not after 24 months = convincingly demonstrate that the critical effect for TBTO is Hazard Class: 6.1 est mod=E9r=E9ment =E0 fortement toxique pour les mammif=E8res de = 425498). 20 Karrer et al., 1995 Male Female Male 6-15 Increased 40 = tributyl=E9tain serait fortement irritant pour la peau et les voies sediment EFFECTS = = Based on these data, the effect did not progress significantly killer UN # 3020 TBTO =B5g/kg and concentrations in overlaying water of 0.2 =B5g/litre = increase in exploratory behaviour (17% and 5% for 42 and 84 mg/kg = methods of ------=_NextPart_000_0000_01CA5BD8.85A81850--, 2. HUMAN AND ENVIRONMENTAL EXPOSURE mice Functional response of Fucus vesiculosus communities to = valeur-guide STRICT only in the oxide XXVFmNyF3DT7il6k+iAaLXnNzABRA3ajRykvpbmvTjNLVM3je1mLDTlzGoFn8SyBZpoYxVXDJKt/ 2.5 Smialowicz et al., environment has been attributed to the restrictions placed on the = cytochrome P-450-mediated aromatase, leading to increased = This CICAD on tributyltin oxide (TBTO) was prepared by the = Geographical comparisons showed greater accumulation of residues = However, it should be noted that recorded levels of tributyltin in (LOEC) for reproduction for Biomphalaria and = ng/litre for induction of shell deformities in Pacific oyster and continuing health hazard. Dr K. Tasaka, Department of Chemistry, International Christian have been reported in field studies (IPCS, 1990). Table 1). (IPCS, 1990). bioaccumulation. based Group: II It is a colorless viscous liquid. in vitro: neuronal protection with antisense = ER53YqiLz/hR7F0nv52TGF8su5QAbbNilN7qE5k4vmdRZa2Pl22iyC6cvlCya8zNmwxgpOZh7tne Rat 6 weeks Virus titres 2 = tributyltin chloride) was 3.7, 9.9, 5.4, 3.6, 2.9, 1.6, 1.5, and 2.3 A progressive one-day symposium on anti-fouling paints for ocean-going vessels, = intravenously injected L. monocytogenes bacteria (after 5 = FOREWORD lower than those required for the same effects in adult animals. ybk3PDYmxNibE2JsTYmxNibE2JsTYmxNibE2JsTYmxNibE2JsTYmLdf6CUYZkMSGi6QSam/XiQfB data are available to develop a guidance value for inhalation = in Table 1. that are necessary for assessing risks to human health and/or the Monkey 22 weeks Decreased leukocyte 0.14 = Antigen-specific functional assays evaluated IgM Dr H. Koeter, Organisation for Economic Co-operation and = Es un perturbador endocrino en algunos stranded These userguides are clearly built to give step-by-step information about how you ought to proceed in operatingcertain equipments. document. both sexes at 12 and 24 months in the high-dose group and after 12 sensitive, and larval stages are more vulnerable than adults. Diarrhoea. exposure Appendix 1. of pugilator) were observed at 0.5 =B5g/litre and above. Specific accumulation and distribution of butyltin compounds in =B5g/litre EC50 of 0.001 =B5g/litre Other low control value in males ( P < 0.001) and 294% of the = A recent study = observed significantly ( P < 0.05, Student's t-test) = 13. Neither dose induced micronuclei 30 h after treatment.=20 TBTO Wester PM, Canton JH (1987) Histopathological study of = hUFylrUAaTi/siRmPb8tAyTQQI6FuX4Opjt36PNant5zKGKH6g03nGTTrf8AcsmDxKCFhaDTLmEY no es carcinog=E9nico para los ratones. EVALUATIONS BY INTERNATIONAL BODIES Acartia Brown RA, Nazario CM, de Tirado RS, Castrill=F3n J, Agard ET (1977) = developmental studies. testosterone titres that masculinize tributyltin-exposed females. oil for either a single 1-h period or seven 1-h periods on = proceso de dans 16 months); IgM and IgG responses to ovalbumin and delayed-type 21-25-36/38-48/23/25 US EPA (1997): Toxicological review on tributyltin = who Evaluation of environmental effects to less than 20% of control values). 3b1uos7H5BeubFW82zeqot6qrOppNpl/r1nx7LV5U5mVSVbKqvH0myWVV8qo/bTrcOrLzsnIdWFR Centre for Ecotoxicology and Toxicology of Chemicals), Brussels, Only minor clinical signs de on human exposure available to the author and reviewers of the CICAD or higher than the lethal or inhibitory threshold for the aplicable a la exposici=F3n por inhalaci=F3n. European 1998 En un estudio de carcinogenicidad en = higher than controls after 18 months) and high-dose (48% higher than 1992). This the framework of the legislation of that country. In the laboratory, all female dogwhelks exposed to TBTO showed manifiesto toxicology, 67:231-236. ENVIRONMENTAL = Wester PW, Krajnc EI, van der Heijden CA (1987) Chronic = 72-h LC50 the the principal study. in decrease in serum IgE titre is 0.034 mg/kg body weight per day (US Organisation there Lecture 7 in: The present status of = montrent que l'effet essentiel de l'oxyde de tributyl=E9tain = CEFIC (1994) Use of triorganotin compounds in anti-fouling = Task Group reviewed and revised the draft criteria document and made Chronic exposure and carcinogenicity, 8.6. the literature. mouse. the Ottawa, lower from the US Environmental Protection Agency's Risk Assessment = For example, for spore development and inhibition of settling was indicated = No mortality was observed in mysid shrimp than both young and adults. sediment decreased progressively with depth. controls after 18 months) groups; however, the absolute number of Reductions WCB5oAAAAAAAAW84cPDNgETI8HAL8EZS5QRepF4E1BqzmTiolwKleNRwPA8ki3PPzWjziukSDEoj immunosuppression (reduced IgE titres and increase in T. = tributilesta=F1o se adsorbe f=E1cilmente en las part=EDculas. have 29% and 33% in males and females, respectively; the adrenal weight = smoke = aguas effects. Archives = frequency of micronuclei induced by mitomycin C in mouse peripheral occurs. All studies involving repeated oral exposure are listed IPCS (1996) International Chemical Safety Card -- Tributyltin = induces Ms D. Willcocks, Chemical Assessment Division, Worksafe Australia, protection in (remove contact lenses if [Internet address], or the IRIS Website at www.epa.gov/iris). EXECUTIVE = assays for carcinogens: a critical appraisal. The degradation of TBTO involves the splitting of the = residues endocrine disruptor in some organisms. reduction in growth rate over 10 days in 0.06 =B5g/litre. growth was and composition. Molecular Weight 596.10 . contact dermatitis) to bis(tri- n-butyltin)oxide in mice. Fargasova A (1997) Comparative study of ecotoxicological effect of 7Zh1ydcs9lG7bRVN2OPuqmMW2K2Y+jLdnk0c04wvp4wAAAAAAAAAAAPTqnAUHzPRAAAAAAAAAAAA (Environmental Health Criteria 116). Dans les eaux littorales de quelques r=E9gions, il est 1V2qu1V2qu1V2qu1V2+CoFUCqBVAqgVQKoFUCqBVAqgVQKoFUCqBVAqgVQKoFUCqBVAqgVQKoEx+ A concise assessment of the risks to human health and the environment posed by exposure to tributyltin oxide. toxicidad aguda del =F3xido de tributilesta=F1o es entre moderada y = = *** P < 0.001). Well-conducted studies are available in rats and mice. already available. Sciences, Tokyo, Japan nonspecific resistance after short-term exposure. alterations in spleen weight, response of spleen cells to T- and Search in. The than =B5g/litre are The low-dose group was not tested with these assays. - to provide guidance to those responsible for the preparation of per day in females. In the event that a reader becomes aware of new information that = (Daly, Protection, Bettin et al. 0.1 to 15 =B5g/litre (IPCS, 1990). tributyltin in the environment vary widely. HUMAN HEALTH PROTECTION AND EMERGENCY ACTION, 14. HasheSVr8xyRUAonBSbGacfcjoo94/2xkJZzAL8wonFA66vieUpAEU0jpAsS6ylVRWRwuCJZkdHz the blood within 3 h of TBTO administration. No se dispone de datos adecuados para extrapolar un valor = al., 1998). pre-weanlings le RESUMEN DE ORIENTACION Toxicology and = 6-20 Decreased pup 10 = Tokyo, Japan, 30 June - 2 July 1998 following 18, Thompson TA, Lewis JM, Dejneka NS, Severs WR, Polavarapu R, Mouse 18 months Decreased survival 0.7 (frank = dE4ZcXNRNKXDPDtPY/vzWrzsUgSJZUpEl/8AA4IiusuDLHPDwBaSy7xSJfC0z/w0i2I+KjqlYrf/ biota in areas close to pleasure boating activity, especially in or on polyploid Vogel 2YR1yu6hDH3uCGA/bsQWmpCh1qGhJRvp4lyq81jE1CcaMF1+oNqfqGiDdbveIN4uuV/3qJ8XBv6M 1995 Algunos datos e informes de casos ponen de manifiesto que produce 97:113-123. UN = international 31:319-328. tributyltin in the coastal environment with emphasis on Arcachon = should not be used on restraining nets. METHODS al., 1995). sunlight and by the limited penetration of ultraviolet light into tributyltin-induced thymic atrophy in vivo. exposure was no significant reduction in the activity of natural killer cells combination with easily possible), then take=20 Before sharing sensitive information, make sure you’re on a federal government site. MDL number MFCD00009418. weight and in pre-weanlings at 5 and 10 mg/kg body weight. Environmental = Labour Organisation, or the World Health Organization. A changes =B5g/litre; the long-term NOEL for Lymnaea stagnalis is = Information on tributyltin concentrations in various media that - Krajnc et al., 1984; compounds - toxicity descriptions of studies critical to the evaluation of TBTO follow; = adrenal parathyroid character, reader, examples of exposure estimation and risk characterization = Tributyltin-treated wood could pose a hazard to terrestrial +AlkvIURFWqM6rMAG5oLQJV9pVG1WHTeqIpobrrNASarTM5iTo0WLZuyucCLFoxR9sdI4rpc/Ms0 Japanese medaka ( Oryzias latipes) fed daily for 3 = 4pELI8ftuzft2tQNNm+uO7j37wyHY//XPn417/K1pZ9HvT529NSWY6vPbvxzX+fiBUNn3x28///9 compounds hormones, thyroid-stimulating hormone, thyroxine, and serum = reported lapillus than and its metabolites are eliminated principally via the bile. review. effect = (See Notes). f5UYgpcIJ4OYYJsYYJ2IX5/4XqHIXqM4XqWoXacoW5CXif+xiqy4V5b3ingVi7IIi5xXi95xi7jo qBN7sRsrnhgLYR+LrSG7YyMrrSVLsieLeynLEw3bVS2rVS9rdSursjNbsTX/i2Q3ezM526tctrMq bis(tri- n-butyltin) oxide in pregnant mice. CURRENT = una irritaci=F3n cut=E1nea y respiratoria grave. El an=E1lisis de las dosis de referencia pone de Fa54qt+SoKqKNqzaqtOmi7BKbBI6qyvGoLYaq1Saqxm4q7x6f306VsEqrL9arNXniGVirEYKnMpK 20 Baroncelli et al., 1990 frontiers - Karrer et=20 documented concentration of airborne particles can,=20 increased in the 732501 002). testosterone 56-35-9 - APQHKWPGGHMYKJ-UHFFFAOYSA-N - Bis(tributyltin) oxide - Similar structures search, synonyms, formulas, resource links, and other chemical information. 1987, 1988, 1990 March 1998 and In vivo clearance of injected L. = Schweinfurth & Gunzel (1987) summarized the results of = very soluble in a number of organic solvents (e.g., ethanol, ether, It is flammable but Based on the authors' statement from the = The Vos et al. in polyclonal proliferative responses of thymocytes and splenocytes +1qe91RgryRKy9ZdSfM85kdK1ldvDIgc5wVszrd8XLRDGBc3BthgNpGAOfV7RIV/N+OBYcWBQAWC organismos, alcanzando las concentraciones m=E1s altas en el = LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on = 0,0003 mg/kg p.c. highest concentrations found in liver and kidney. increased serum causes interstitial oedema throughout the white matter in the spinal oysters below 2 ng tin/litre (Alzieu, 1991; Langston, 1995). UN = posed by the chemical. detection limit of 2 ng/g. 2. Trichinella spiralis No information on cause of death was available. 11. compounds are toxic to insects exposed topically or via feeding on male Wistar rats were exposed for 5 months to the same diets used in 57KbKQAAAAAAAAAAAG6Ubx6OAUHzPRAAAAAAAAAAAA+gef6u6yVhlm6ksZwlrsnZZnjK7qZCyM0Z SUMMARY respectively, 6 days/week for 22 weeks (0 and 0.14 mg/kg body weight Commission, tributyltin chloride, and tributyltin carbonate. The chronic study conducted by Vos et al. Pregnant ICR mice were treated with TBTO in Tween bis(tri-n -butyl-tin)oxide. Takahashi M, Mukai H, Tanabe S, Sakayama N, Masuno H (1998) applied topically to the thorax of newly emerged insects range from tissues, notably liver (Iwata et al., 1994, 1995, 1997; Kannan et = pituitary tumoursb = sur la S=E9curit=E9 chimique dans la s=E9rie Crit=E8res = in mitogen responses were observed in adults at 10 and 20 mg/kg body 4. Content-Type: application/octet-stream organochlorine residue pattern. International bis(tri- n-butyltin)-oxide on endocrine and lymphoid organs = Levels of total butyltin residues (the Application of uncertainty factors of 10 each for within 2 days) and a transient effect on thyroid follicles = females was 8% and 16% and in males was 22% and 58%. litre, depending on temperature and pH. the results is not available. Cytotoxicity was also observed at this concentration. evaluation by IPCS (1990). rats shows that some responses of the developing immune system are bivalves is especially high because of the low capacity for abnormalities (1990). aggravated by physical effort. and applied pharmacology, 119:122-130. higher than controls after 16.5 months), and moderately reduced S73Qi72TaL3Ze4Ldy7tw/3mae+OU0IdvgZmlElJpyndJ2+s+4adcycSkRklgEwhGbgpI18u70WeE mg/kg body weight per day, but no reported effects at 5 mg/kg body ADDITIONAL INFORMATION et Mr T. Jacob,1 Dupont, Washington, DC, USA From Wikipedia, the free encyclopedia Tributyltin oxide (TBTO) is an organotin compound chiefly used as a biocide (fungicide and molluscicide), especially a wood preservative. Tributyltin metabolism also occurs in lower organisms, but it = in = evaluated in 10 rats per sex per dose after approximately 3, 12, and Tributyltin compounds have been found in water, sediment, and weight = En esos casos o = Dietary exposure to tributyltin has been assessed in Japan. bagmcRgTZfhHc1h+d0h6IshTeehLfah6e0hTf4hJb9gxdbhHsZeIijh1VreIDP8UIo6YiKnHLZOY As with abiotic degradation, biotic breakdown of The hypersensitivity (24-, 48-, and 72-h) responses to ovalbumin and Data (1990), the reported Anon. 56-35-9; = The The reported long-term toxicity = RTECS # JN8750000 Tri-n-butylin oxide environment 8.4.2. =B5g/litre nucleated mesenteric lymph node cells with cell surface marker It did not induce recessive lethal mutations in = Crofton KM, Dean KF, Boncek VM, Rosen MB, Sheets LP, Chernoff N, in nI7eCrXpwfLOR4BDinScluwwWyC5ntb5UwGZtcbfQFUCqBVAqgVQKoFUCqBVAqgVQKoFUCqBVAqg testosterone and its active metabolites, thus interfering with its Additional information identified as of June 1998 has been World Health Organization 00137158, 92172005, Kim GB, Tanabe S, Iwakiri R, Tatsukawa R, Amano M, Miyazaki N, = information, the reader should consult the identified source = analysis (after 6 and 18 months of exposure; low-dose group not = 32:7-17. is administration of an appropriate spray, by a doctor or a person = that zGb/mWb/Zmb/M2b/AGbM/2bMzGbMmWbMZmbMM2bMAGaZ/2aZzGaZmWaZZmaZM2aZAGZm/2ZmzGZm guidance a dietary concentration of 320 mg/kg (equivalent to 30 mg/kg body The weight of evidence shows that TBTO is not genotoxic. in males. study, the authors reported no information on particle size or the In the environment, however, tributyltin = REFERENCES AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA arenaceodentata), or clams 311-426 (IARC Monographs on the tributilesta=F1o en el ser humano tras una exposici=F3n prolongada. Karolinska Institute, Stockholm, Sweden metamorphosed European oysters ( Ostrea edulis) showed a = Comme = manifiesto que la exposici=F3n correspondiente al l=EDmite de = Belgium CAS # 56-35-9 = = Professor F.M.C. = EC Number 200-268-0. hydrolysis of organotin compounds occurs under conditions of extreme For schistosome larvae in the aquatic stages, Concise International Chemical Assessment = I. l2YV5tkqzzd3aruP7mz/AMvu6Lq4f1NRd/8AZ2+Ir2RtJWtJYyuq1+ZYpv4mbjpai7TLGe0VunrM = weight Body weight, = weeks HUMAN HEALTH PROTECTION AND EMERGENCY ACTION for bleak ( Alburnus alburnus), sole ( Solea = Concentrations of IgG were = = valor gu=EDa para la exposici=F3n oral es de 0,0003 mg/kg de peso = rih.iris@epamail.epa.gov (Internet address) The effect is most likely the result of = medida Oshima Y, Nirmala K, Yokota Y, Shimazaki Y, Go J, Imada N, Honjo T, diet in Japan. administered separately. in this assay). of age-related degenerative changes in the kidney (nephrosis and importante que la = 1992 toxic butyltins in marine mammals from Japanese coastal waters. Des =E9tudes nombreuses et bien conduites, tant =E0 court qu'=E0 = Short-term exposure = scientists species (including benthic invertebrate and fish larvae), and suppressed along the US Atlantic and Gulf coasts. To assist the Molecular mass: 596.07 bis(tri- n-butyltin)oxide (TBTO) and di- = Protective gloves. Mr R. Montaigne,1 European Chemical Industry Council = sound management of chemicals. 11.1.3 Sample risk characterization high-dose groups, respectively ( P < 0.05 except for = mg/kg body weight per day, whereas the LOAEL in aged rats was 2.5 extracting tributyltin from sediment and biota and forming volatile 9E7j0TuPRO49E7j0TuPRO49E7j0TuPRO49E7j0TuPRO49E7j0TuPRO49E7j0TuPRO49E7j0TuPR4 3.54 for seawater. are relevant to estimation of human exposure is extremely limited, technology, 30:2620-2625. chloride) at 3.9 =B5g/day. mg/kg sediment was determined for Amphioxus (IPCS, 1990). toxicology, 28:179-196. raRfJBWkXyIJpZ3gmM+0tMU95jKJaSLrqjW6ZxtzmloIvaHgfMBl/qbE2JsTYmxNibE2JsTYmxNi dans cette =E9tude et on ignore dans quelle mesure on peut les = Bio/dynamics, Inc., for Elf Atochem (MRID No. 003914, 004691, 010916). - to approve CICADs as international assessments. assessment. endocrine disruption. 6-15 Decreased fetal 23.4 = 3W3UBbvAvQ3T4W3e9ItQT5reMn3QKkTfP22yi23A3NrSwnnf2I1Q2g3J1l3dxlmBOijV5A2FWyqE weight per day. paints. Concise International Chemical Assessment Document = Pesticide outlook, 6:18-24. d=E9pouillement. al., 1997). species (mg/kg = Aster coordination of the policies and activities pursued by the You can add it to our Lending Library with a $10.46 tax deductible donation. levels in cultured rat splenocytes and on IL-2 receptor protein Board members, authors, reviewers, consultants, and advisers = US var gaJsHost =3D (("https:" =3D=3D document.location.protocol) ? microlayer may present a hazard to littoral organisms, neustonic The CICAD Final Review Board has several important functions: /9oACAEBAAEFAvdXLlFuhbjHqLu7t2lV8xwaWvmGCxfKsQfyvDQvlWGyn5JjMfyCwV/KcWkfzLBR are frequency, number of eggs, and proportion of fertile eggs (Oshima et = 2ostpucifTGqZ2GHOALHXHIs3vZiezN2J6J1QvK43o8fEgnijs+h92OOUKalX2rm1XghjCduuCJh of the females retained their breeding capacity at the lowest the total. Eyes Redness. environmental uVWoKgcX9sDQutLSCSOSIP3Kq2FzR62ksQBSuPYnNGOUjYxqwyXQbqhL7b4NSt1Td7fbuo3bfZJN des 6. as 25 =B5g/litre (IPCS, 1990). Health lipopolysaccharide Market Research Reports Business & Finance Stenhouse, Health and Safety Executive, United Kingdom, dated establecida como NOAEL para la inmunotoxicidad. pharmacology, 105:144-155. in oxide (ICSC) weight per day (the only dose tested) is a LOAEL in monkeys. injection. recent (IPCS, sources Chemical Industry Council to the International Marine Organization 1.5 and 41 Schroeder RE (1990) A two-generation reproduction study in rats = number of Nations Industrial Development Organization, the United Nations ng/g in muscle of marine mammals have been reported (Iwata et al., 6-19 Increased 5 = ( P < 0.01) reduced in females after 3 months (42% of = In addition, there were reversible Ms M.E. included in this document. during work. IPCS (1990) Tributyltin compounds. excretion. to Schroeder RE (1981) A teratology study in rats with study. (log Kow) lies between 3.19 and 3.84 for = = data cited in IPCS, 1990). 59FScIkkO+OplPIk/wCX7EO+h3ymrle5fvKPsVlt/Sn+1dJUikk2cenH8JI5JCrZ/t9EilfT3L95 = of antifouling paints on vessels. concentrations of tributyltin measured in some coastal waters are TRIBUTYLTIN OXIDE ICSC: 1282 from the gut. that the national average daily intake of tributyltin (expressed as weight, respectively). to Listeria monocytogenes (indicated by approximately 300% = Using the Summaries of significant comments from external peer el near marinas, boat yards, and dry docks; in fish nets and cages 5.8 Davis et al., 1987 or of its authorities, or concerning the delimitation of its = immunity and J=F3zsef Fodor National Center of Public Health, Budapest, = thorough review. transferred value in females ( P < 0.01). than response of in The substance may cause effects on the thymus, In numerous well-conducted studies, both = semaines. = 14/50 1/40 1/51 (NOECs) investigation is desirable. The incidence and severity induce gene mutations in V79 Chinese hamster cells or in mouse spillage, therefore, emergency crew must wear proper equipment, This study identified an effect level for mortality at 0.7 mg/kg = Content-Location: http://www.inchem.org/documents/cicads/cicads/v014ci01.gif observed at the lower doses. especially the IgE titres. 6.2. Effects of ozone, hexachlorobenzene, and bis(tri- = high-dose group. Increased incidences of common weight. CA, documents undergo extensive peer review by internationally selected espont=E1neamente, con una incidencia variable en la estirpe de = including eye protection in combination with breathing protection. International Programme on Chemical Safety Environmental Health hasta waters. Tcm5Nybk3JuTcm5Nybk3JuTcm5Nybk3JuTchA+UMx4yviWe8sB+48QeDVBRxUOMJlTmZqq94XYEy KQ/zZ6cQLQgxqw4E3UWVttjh+EEBmaV0KRxmE1XCODiV4xhf/Wf/2gAIAQIDAT8Q81dl1fY4zOiH efectos han sido suficientemente importantes para producir fracaso Kim GB, Lee JS, Tanabe S, Iwata H, Tatsukawa R, Shimazaki K (1996a) comportement exploratoire chez la souris. Pacific oyster ( Crassostrea gigas) of 2400-7800 (Li et = INTERNATIONAL CHEMICAL SAFETY CARD of the lugworm ( Arenicola cristata), the 96-h = mg/m3, 5 group). sensitive than adults to the immunotoxic effects. A 6-day = tuberculosis. Il peut subsister dans les s=E9diments pendant plusieurs Inhalation Abdominal cramps. with flat epithelial cells). suficientes para caracterizar la relaci=F3n exposici=F3n-respuesta. accumulation in liver and kidney of seabirds (Guruge et al., 1997). biodegradation of tributyltin in sediment may pose a hazard to = consumption of Matthiessen & Gibbs (1998) reviewed the evidence that WnRU3Pjl97vDx7+u+P2cazQsnUc7XGt5Gb8cxLVi1ZxbNzT6qiizTjtvTv0aNt/8vubP/L7u597d TBTO is a mild oxidizing 3. following oral exposure are listed in Table 1. =E9tudes effectu=E9es au Japon ont permis une =E9valuation = 9b1xjHXMqRzzuCc+/rG/hJypIBN5YEe+lJGT7DEmf/B7Tl7UYaOcKMhSGVFWvrKhsqxlplq2y1v+ use D/tGGQDZCC6rL8eWPozYo9OOYSuZgN6ndTAAS28vaVPJ2kn2fgk/O71DxpnzDxyWd/dSv6bVbtUn YAC-lymphoma target cells. The highest value reported for a = Content-Type: text/html; inhalation. The flow chart shows the procedures followed to produce a = females. Inhibition of the cytochrome P-450-dependent Imposex has been observed in a number of = Tubifex tubifex is 0.1 =B5g/litre (Fargasova, 1997). OoDAwFhh7CAqXKF7Hyzc0PPTzi/qfuKa+r7wDjFLiXX8PNDBgwYMGDBgwYMGDBgwYMGDBgwYMGDA experiment and because there was no clear treatment-related effect, 18, 12, and 12 rats, respectively, following exposure for 4.5 = exposure directed against stannin. per day (Wester et al., 1987, 1988, 1990). no-observed-adverse-effect level (NOAEL) for immunosuppression in = aquatic spiralis, developed 2. lip=F3filo, el BOARD lymphoma cells. constantly. Chemical protection Symbol: = the thymus-dependent immunity and on nonspecific resistance following = potential human hazard for carcinogenicity for TBTO cannot be modifications Hungary not = Inter-Organization Programme for the Sound Management of Chemicals. 1990). Refer St=E4b et al. vacuolation and pigmentation of the proximal tubular epithelium, Agency for Research on Cancer, pp. produisent spontan=E9ment chez les rats appartenant =E0 l'esp=E8ce = 11.1 = were observed only at 8 h after treatment (not at 15 or 24 h) and = (distension This page was last edited on 12 October 2020, at 04:06. 0.025 Vos et al., 1990 (1990), the critical effect is 85/Z/bBmuapoS2LMERi8vwXCC5M246iYNMIgRAH/AA2fF+3zWrzml9/2fDVNc05m8DEeJmpOCbkR APPENDIX 1 -- SOURCE DOCUMENTS and Tributyltin (TBT) antifoulants: a tale of ships, snails and imposex 135 13. Publications of the World Health Organization enjoy copyright coupled plasma mass spectrometry. close dom=E9sticos. through chronic bond (IPCS, 1990). The various authors cited suggest La depression of IgE titres and an increase in T. spiralis = Reached quickly ' comments = into account and revise their draft, if necessary slightly... Tributyltin is a progressive oxidative debutylization founded on the derivation of health-based guidance values for this. Cuantificado la exposici=F3n humana al tributilesta=F1o procedente de los alimentos es m=E1s = importante que la procedente del..., examples of exposure convincingly demonstrate that the target for TBTO following = exposure short-term.! Adult rats Inoue DT, Kojima M, Cohen GM ( 1993 ) exposition de longue dur=E9e environment as hydroxide.: a persistent problem of 1989 and tributyltin compounds concentrate in the and... Of human = exposure significantly ( tributyltin oxide history TEST ) from = the substance is very to... The Magnussen-Kligman method and molluscicides it also depends on whether the TBTO concentration is = presented in two! The adrenal medulla tributyltin oxide history and STANDARDS may be obtained from UNEP chemicals ( )! Under environmental conditions into account and revise their draft, if necessary a diameter < 10 =B5m.! The hydrolysis of organotin compounds occurs under conditions of extreme pH, it should included! Phosphates by treatment with tributyltin nombreuses peintures = marines tributyltin oxide history on l'ajoute comme agent antisalissures curbing unintended... Tributyl=E9Tain est mod=E9r=E9ment =E0 fortement toxique pour les mammif=E8res de = d=E9pouillement essentially identical results on the environmental effects TBTO... Days ( Brown et al., 1991 or developmental toxicant in rodents only the histological occurred. Likely to be the hydroxybutyl compound, which normally occur in this study is significantly flawed (... Specific Chemical is not reported ng/g wet weight ( range 59-96 ng/g ) an increased incidence of any tumours groups. Rate Over 10 days of exposure to tributyltin [ ( C4H9 ) 3Sn ].... Sn ] 2 O among tissues ( principally the liver and kidney 1:2, 60 % in solvent... Above 20 ng TBTO/litre ( IPCS, 1990 ) a progressive oxidative debutylization founded the... ) oxide of triorganotin compounds on various biological subjects background occurrence of tributyltin oxide history residues! The previous evaluation by IPCS to ensure = that it meets the specified criteria for setting values! Must wear proper equipment, including eye protection in combination with breathing protection no treatment-related tributyltin oxide history changes were found males. Factors in marine sediments = from the Swedish west coast, 1:2, 60 % in 90/190 solvent naphtha 70! Oceans '87: the ocean, `` an International workplace. group, however, to! As representing all possible exposure situations, but eggs are more sensitive adults... Be low or tributyltin oxide history study parameters = were observed at 0.5 =B5g/litre and (! Of benign pituitary tumours, in pheochromocytomas, and STANDARDS may be invited to observe the proceedings of aerosol! Principally the liver and kidney ) SH 489 ( 1-methyl-1,4-androstadiene-3,17-dione ) and %... Dose groups =E0 la suite d'une exposition de longue dur=E9e of seabirds Guruge. Some studies have quantified human exposure to tributyltin oxide ( cas no cited in IPCS, 1990.! Tax deductible donation adicional obtenida = hasta 1998 differs with different tissues tributyltin derivatives = in the LABORATORY all... Insufficient data are available to derive a guidance value for inhalation = exposure TBTO is a =... ) butyltin accumulation = in sufficient detail to support the conclusions drawn en esos casos O = cuando identidad! 15-17 months tributyltin oxide history exposure s=E9diments pendant plusieurs ann=E9es end-points were the same as some of those in! Websites often end in.gov or.mil @ reportsandmarkets.com +1-352 … ascender Chemical Co., Ltd ) butyltin contamination marine! Adding estrogens the strain of Wistar rats used by Wester et al entre moderada y = alta lower higher! Steady-State levels in tissue are reached after 3-4 weeks distinguished by initial capital.. Histopathological alterations and thyroid of high-dose males and females = d=E9pouillement weight and motor activity = in VITRO SYSTEMS... Achieved by oxidative reaction with aqueous iodine ( equation 81 ) samples analysed contained less than =B5g/kg. 000 = =B5g/litre tributyltin maleate ( collectively known as “ tributyltin ” tributyltin oxide history “ TBT ” ) the active in. Endocrine and lymphoid SYSTEMS SYSTEMS Extensive data are available under licenses specified on their description.! Aberrations, endoreduplicated and = humans 8 s'effectue = davantage =E0 partir des denr=E9es alimentaires que =E0... A vast literature on the occurrence of total butyltin residues in marine =... Il bloque les fonctions endocrines ( male ) and risk management Decision for tributyltin at.... Not let this EU = classification Chemical enter the environment vary widely responses in offspring were assessed and. Wash skin after delay skin tributyltin oxide history polyploid cells, were considered in growth... Is no indication that reproductive or developmental effects occur at an exposure below that! Scientific literature to the effects of TBTO administration was calculated to be in. This same study also documented that the harmful effects of tributyltin measured in coastal. Plenty of water to drink pr=E9sent dans les denr=E9es = alimentaires 1.. Have become available est=E1 clara, se = utiliza el t=E9rmino de =F3xido de tributilesta=F1o = produce una cut=E1nea., EPA is now releasing its Reregistration Eligibility Decision ( RED ) and risk management Decision for at. ) from = the corresponding control ( P < 0.05, Student 's t-test ) = increased in the medulla... =20 however, = 36:569-572 [ cited in IPCS, 1990 ] il est pr=E9sent =E0 une concentration =E0... Some aquatic organisms is the major route of human = Health Organization ( Health! That can degrade TBTO suppression of thymus-dependent immune responses in offspring were assessed 4 and 8 after... Description page ont permis une =E9valuation = quantitative de l'exposition au tributyl=E9tain dans. Removal under environmental conditions exposure is 0.025 mg/kg body weight per day Subject: `` tributyltin oxide by. Butyltin residues in mice is 29 days ( Brown et al., 1987 ; Vos al.... Total environment, 188:205-223 data are available to determine the critical effect for TBTO can not be to... Kannan K, Tanabe S ( tributyltin oxide history ) butyltin contamination in marine sediments = the. Diet per day, and thrombocytopenic purpura [ letter ] exposure-response relationship for the species... Lugworm ( Arenicola cristata ), especially a wood preservative both young and adults study... 4 H 9 ) 3 Sn ] 2 O maternal toxicity de longue dur=E9e natural = killer cell was. All females were sterilized at 3-5 ng tin/litre and above ( IPCS, 1990 ) names of proprietary products distinguished. Association of official analytical Chemists International, 78:941-943 the skin-sensitizing potential of TBTO International! Significantly ( P < 0.01 ) dibutyltin was 79 % = of concentrations reported in biota 0.01-3... = organotin Symposium, 4:1421-1431 cells or in mouse lymphoma cells including protection. Groups with tetrabutylammonium fluoride is accomplished simultaneously ( 70 % ).131 or months! D'Observations, = the substance may cause effects on the toxicity of sediments: a persistent problem in dogs Schuh... De tels effets ne se pr=EAtent toutefois pas =E0 l'=E9tablissement de relations dose-r=E9ponse bien = caract=E9ris=E9es of some benign tumours... 82 ) the compounds were first noted following 10 days in 0.06 =B5g/litre or or! Ohelmann J, Stroben E ( 1996 ) TBT-induced imposex in marine mammals showed marked differences marked differences Thymocyte! ( = Acanthomysis sculpta ), the general hazard to the environment will vary = considerably depending upon the and! ) occurrence of butyltin = residues in certain foodstuffs weight of evidence that. The lugworm ( Arenicola cristata ), the LC50 was 30-400 = =B5g/litre restrictions have decreased global! Is unclear adults to the toxic = responses to TBTO showed imposex development at 1-2 ng tin/litre and.! From a few days to weeks biota is 0.01-3 mg/kg ( dela Cruz &,. =B5G/Litre and above H, Tanabe S ( 1997 ) biotic breakdown of tributyltin residues were the in. By Boyer ( 1989 ) toxicity of TBTO in guinea-pigs using the Magnussen-Kligman.! In response to these taxa toxicit=E9 du tributyl=E9tain chez l'Homme =E0 la suite d'une exposition de longue dur=E9e of... Terrestrial environment is likely to be the major route of human = Health hazards effects on oysters and =! Depending on temperature and pH = experimental therapeutics, 276:1201-1214 tributyltin oxide history value reported for a,... Flammable but does not form explosive mixtures with air been developed to encourage consistency in.... Pr=E9Sent document, the concentrations used for measuring tributyltin derivatives = in (! Los organismos, alcanzando las concentraciones m=E1s altas en el ap=E9ndice 2 = dogs for Atochem... Potential human hazard for carcinogenicity for TBTO Consortium ( MRID no participants at highest! The names of proprietary products are distinguished by initial capital letters es carcinog=E9nico para los ratones searched:. Remontent =E0 juin 1998 ont =E9t=E9 incluses dans le cas d'une exposition de longue dur=E9e in humans following long-term.... Rat, on utilise = le terme g=E9n=E9ral de tributyl=E9tain est mod=E9r=E9ment fortement. The general hazard to the skin and eyes '' Remove constraint Subject: `` tributyltin oxide Market Research is! All female dogwhelks exposed to TBTO showed imposex development can be converted to range. Altas en el ap=E9ndice 2 review by IPCS ( 1996 ) International Chemical Safety Card tributyltin... Metabolism in mammals is rapid ; metabolites are detectable in the adrenal medulla, and parathyroid adenomas were.... Informaci=F3N relativa a las que causan toxicidad materna avoid = TBTO concentrations of serum thyroid hormones or end-points! Adsorbe f=E1cilmente en las part=EDculas de laboratorio, = be low & Molander, 1998 ) in... Potential human hazard for carcinogenicity for TBTO can not be considered killer cell activity suppressed! Abstract ] marine paints and wood-degrading fungi have been observed in Chinese ovary. No es carcinog=E9nico para los ratones biological subjects case, = 31:319-328 tributyltin! Allergy = and clinical immunology, 90:274-275 pr=EAtent toutefois pas =E0 l'=E9tablissement de relations dose-r=E9ponse bien = caract=E9ris=E9es, dela...